Archive for the ‘Anxiety’ Category

https://www.sciencedaily.com/releases/2019/02/190211083204.htm

A seventy year old man, without cannabis experience, ate 90mg THC, or about 3-10 times the normal dosage, depending upon his body weight.  So, he got seriously buzzed and freaked out.  Panic attack!  It was THAT that caused tachycardia and likely constrictions in blood flow due to adrenaline and panic.  That’s all.  It’s disingenuous to declare the cannabis as causal, even though it indirectly may be.  The point is that cannabis does not cause cardiovascular problems, but panic attacks apparently do.  What if the guy saw something on television that freaked him out and caused a panic attack?  Would these “researchers” declare television to be dangerous to patients with cardiovascular disease?  Only if they had a hidden agenda.

Cannabis is generally relaxing, but blood pressure can be slightly raised while under its effects.  Research shows that cannabis is a vasodilator, if anything, so it should be beneficial to cardiovascular patients.  This paper implies otherwise, but did correctly state: “The patient’s cardiac event was likely triggered by unexpected strain on his body from anxiety and fearful hallucinations caused by the unusually large amount of THC he ingested. His sympathetic nervous system was stimulated, causing increased cardiac output with tachycardia, hypertension, and catecholamine (stress hormone) release. After the psychotropic effects of the drug wore off, and his hallucinations ended, his chest pain stopped.”  [emphasis mine]

So, this really has nothing to do with cannabis, but is about fear/panic, which could be caused by many different subjective experiences.  What if the man had eaten peanuts with dinner– would the researcher’s declare that he had a peanut allergy?  Remember– “correlation is not causality”.  Further, the paper talked about “…since the THC content of the substance had increased significantly from three percent to 12 percent.”  This meme is common to BULLSHIT papers which tout the “danger from increased potency cannabis”.  Increased potency simply means that less is needed.  Just as you don’t drink vodka by the pint, like you do beer, you don’t smoke an entire joint like people did 50 years ago.  One or two hits usually suffices, just like a shot of vodka, not a liter.  So, anytime the “increased potency” meme is used, it discredits the paper’s authors because it indicates either extreme naivete’ or an anti-cannabis agenda.

AuntieBS

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https://www.sciencedaily.com/releases/2018/09/180910173731.htm

Very effective medication for many conditions.

AuntieBS

https://www.sciencedaily.com/releases/2018/04/180419100110.htm

Another useful data point.

AuntieBS

https://www.sciencedaily.com/releases/2018/02/180215153923.htm

This paper cites the need for more, controlled research into medical cannabis uses and no one would argue that, but their usage and conclusions are questionable.  First, for pain relief, cannabis has an interesting property.  It only reduces pain slightly, but renders the patient not caring about it, thus making the pain more tolerable.  Unrealistic expectations also can interfere with analgesic properties.  Given cannabis’ sedative effects, it is often best used at night, when opiates would wear off, waking the patient, while cannabis lasts the night through.  Cannabis should be administered orally for a longer, time-release, effect, with 1-3 hours (2 typ) allowed before effects begin.

Further, some of the pain relief may be through defacto hypnosis, since cannabis can be considered a hypnotic drug, and therefore be heavily modulated by the patient’s mindset.  Inexperienced patients may feel anxiety, thereby rendering cannabis less effective for pain and sleep.

It is important for the prescribing physician to determine the patient’s familiarity and experience with cannabis before prescribing, as such patients often know subjectively how well it works for them.  Novice patients need be counseled on what cannabis does and does not do, with sufficient disclaimers so as to not give unrealistic expectations.  “This may make it easier for you to sleep through the pain and you might experience a bit of dizziness if you get up at night”, would be appropriate advice.  Note that pain is not mentioned.  “If you wake and still notice pain, you may find it diminishing and becoming more tolerable as you drift off to sleep” is another bit of good advice.  Perhaps all the analgesic properties are due to self hypnosis, induced by the drug, so much more research is needed, but the subjective insistence as to its effectiveness should not be dismissed.

AuntieBS

 

Low levels tetrahydrocannabinol, or THC, the main psychoactive compound in marijuana, does reduce stress, but in a highly dose-dependent manner, new research confirms.

Source: Low-dose THC can relieve stress; more does just the opposite — ScienceDaily

 

It should also be pointed out that experience with cannabis plays a role in anxiety reduction.  An inexperienced user may experience paranoia and increased anxiety at a much lower dose than an experienced user.

AuntieBS

A natural signaling molecule that activates cannabinoid receptors in the brain plays a critical role in stress-resilience — the ability to adapt to repeated and acute exposures to traumatic stress.

Source: Natural chemical helps brain adapt to stress — ScienceDaily

Why is THC psychoactive and CBD is not? How can one cannabinoid alter the mind so profoundly, and the other seemingly not at all?

Source: CBD vs. THC: Why is CBD Not Psychoactive? | Leafly